Imagine a journey through the cinema's history to recover the figure of the doctor in the last century. At the same time, we have found that the progress of medicine has conditioned the stories told on the big screen. Cardiology has achieved a leading role at the cinema when technological innovations have begun to emerge, from the '60s onwards. Indeed, the success of acute myocardial infarction network stimulated the idea of using a movie - Questione di cuore - to tell the course of coronary artery disease in parallel to the life of the two movie's characters, as well as to become a project for a scientific meeting shared with our patients.