The relationship between perceptions and self-paid hepatitis B vaccination: A structural equation modeling approach

PLoS One. 2018 Dec 6;13(12):e0208402. doi: 10.1371/journal.pone.0208402. eCollection 2018.

Abstract

Background: Malaysia has a comprehensive, publicly-funded immunization program for hepatitis B (HepB) among infants, but adults must pay for the vaccine. The number of HepB carriers among adults is expected to increase in the future; therefore, we examined the impact of five constructs (cues to action, perceived barriers, perceived benefit, perceived severity, and perceived susceptibility) on adults' willingness to pay (WTP) for HepB vaccine; secondarily, we examined the association between perceived barriers and perceived benefits.

Methods: Adults were selected through a stratified, two-stage cluster community sample in Selangor, Malaysia. The reliability, convergent validity, and discriminant validity of the measurement model were assessed before implementing a partial least squares structural equation model (PLS-SEM) to evaluate the significance of the structural paths.

Results: A total of 728 participants were enrolled. The five constructs all showed adequate internal reliability, convergent validity, and discriminant validity. There was a significant, positive relationship to WTP from constructs (perceived barriers [Path coefficient (β) = 0.082, P = 0.036], perceived susceptibility [β = 0.214, P<0.001], and cues to action [β = 0.166, P<0.001]), and the model all together accounted for 8.8% of the variation in WTP. There was a significant, negative relationship between perceived barriers and perceived benefit [β = -0.261, P<0.001], which accounted for 6.8% of variation in perceived benefit.

Conclusions: Policy and programs should be targeted that can modify individuals' thoughts about disease risk, their obstacles in obtaining the preventive action, and their readiness to obtain a vaccine. Such programs include educational materials about disease risk and clinic visits that can pair HepB screening and vaccination.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Algorithms
  • Cross-Sectional Studies
  • Discriminant Analysis
  • Female
  • Hepatitis B Vaccines / economics*
  • Humans
  • Malaysia / epidemiology
  • Male
  • Medically Uninsured
  • Middle Aged
  • Models, Theoretical
  • Patient Compliance / psychology*
  • Patient Compliance / statistics & numerical data
  • Surveys and Questionnaires
  • Vaccination / economics
  • Vaccination / psychology
  • Vaccination / statistics & numerical data*

Substances

  • Hepatitis B Vaccines

Grants and funding

This study was funded by the Putra Grant - Putra Graduate Initiative (IPS), grant number GP-IPS/2013-939220. ALW’s salary was funded through a fellowship from the PhRMA Foundation. HH is a recipient of an Australia Awards Scholarship (AAS) from the Department of Foreign Affairs and Trade, Scholarship for International Research Fees (SIRF) from The University of Western Australia and NHMRC Centre of Research Excellence in Emerging Infectious Diseases (CREID) Scholarship.