CHD2: One Gene, Many Roles

Neuron. 2018 Dec 5;100(5):1014-1016. doi: 10.1016/j.neuron.2018.11.036.


Mutations in the chromodomain helicase DNA-binding 2 (CHD2) gene have been found in patients with a range of neurodevelopmental disorders. In this issue of Neuron, Kim et al. (2018) showed that Chd2 haploinsufficiency compromises cortical development, synaptic function, and memory in mice.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • DNA-Binding Proteins / genetics*
  • Humans
  • Memory, Long-Term
  • Mice
  • Mutation
  • Neurogenesis*
  • Neurons


  • CHD2 protein, human
  • Chd2 protein, mouse
  • DNA-Binding Proteins