Nucleoside and N-acetyldopamine derivatives from the insect Aspongopus chinensis

Fitoterapia. 2019 Jan:132:82-87. doi: 10.1016/j.fitote.2018.12.005. Epub 2018 Dec 4.

Abstract

Two new nucleoside derivatives, named asponguanosines A and B (1 and 2), three new N-acetyldopamine analogues, aspongamides C-E (3-5), one new sesquiterpene, aspongnoid D (6), and three known compounds were isolated from the medicinal insect Aspongopus chinensis. Their structures including absolute configurations were assigned by using spectroscopic methods and ECD and 13C NMR calculations. Biological activities of compounds 3-7 towards human cancer cells, COX-2, ROCK1, and JAK3 were evaluated.

Keywords: Aspongopus chinensis; COX-2; Insect; JAK3; N-acetyldopamines; Nucleosides.

MeSH terms

  • Animals
  • Carbon-Carbon Lyases / chemistry
  • Carbon-Carbon Lyases / isolation & purification
  • Cell Line, Tumor
  • China
  • Cyclooxygenase 2
  • Cyclooxygenase Inhibitors / chemistry
  • Cyclooxygenase Inhibitors / isolation & purification
  • Dopamine / analogs & derivatives*
  • Dopamine / chemistry
  • Dopamine / isolation & purification
  • Heteroptera / chemistry*
  • Humans
  • Janus Kinase 3 / antagonists & inhibitors
  • Molecular Structure
  • Nucleosides / chemistry*
  • Nucleosides / isolation & purification
  • rho-Associated Kinases / antagonists & inhibitors

Substances

  • Cyclooxygenase Inhibitors
  • Nucleosides
  • N-acetyldopamine
  • Cyclooxygenase 2
  • PTGS2 protein, human
  • JAK3 protein, human
  • Janus Kinase 3
  • ROCK1 protein, human
  • rho-Associated Kinases
  • Carbon-Carbon Lyases
  • trichodiene synthetase
  • Dopamine