Intraclass Correlation Coefficients for Planning Cluster Randomized Trials in Community-Dwelling Older Adults

J Aging Health. 2020 Jun/Jul;32(5-6):252-258. doi: 10.1177/0898264318816216. Epub 2018 Dec 6.

Abstract

Objectives: With the emerging trends, more cluster randomized trials will be conducted in older adults, where facilities are randomized rather than individuals. Similarity of individuals from a facility (intraclass correlation coefficient/ICC) plays a critical role, but not readily available. We document ICCs for measures commonly used in community-dwelling older adults and discuss implications. Method: Secondary analysis of a range of baseline measures from the On the Move cluster randomized trial, whose ICCs were computed using a linear mixed model. Results: Self-reported disability measures related to facility characteristics and sense of community had the greatest ICCs (>0.10), while mobility performance measures had 0.05 to 0.10, and cognitive measure 0.11. Discussion: The ICCs for measures commonly used in older adults are of a sufficient magnitude to have a substantial impact on planned sample size of a study and credibility of results, and should be taken into consideration in study planning and data analysis.

Keywords: cluster randomized trials; clustering; community-dwelling; intraclass correlation coefficient (ICC).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Cluster Analysis*
  • Female
  • Humans
  • Independent Living / statistics & numerical data*
  • Male
  • Randomized Controlled Trials as Topic / methods*
  • Research Design*
  • Sample Size