Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019;177:23-62.
doi: 10.1007/978-3-030-03502-0_2.

Molecular Biology of KSHV in Relation to HIV/AIDS-Associated Oncogenesis

Free PMC article

Molecular Biology of KSHV in Relation to HIV/AIDS-Associated Oncogenesis

Meilan He et al. Cancer Treat Res. .
Free PMC article


Discovered in 1994, Kaposi's sarcoma-associated herpesvirus (KSHV) has been associated with four human malignancies including Kaposi's sarcoma, primary effusion lymphoma, a subset of multicentric Castleman's disease, and KSHV inflammatory cytokine syndrome. These malignancies mostly occur in immunocompromised patients including patients with acquired immunodeficiency syndrome and often cause significant mortality because of the lack of effective therapies. Significant progresses have been made to understand the molecular basis of KSHV infection and KSHV-induced oncogenesis in the last two decades. This chapter provides an update on the recent advancements focusing on the molecular events of KSHV primary infection, the mechanisms regulating KSHV life cycle, innate and adaptive immunity, mechanism of KSHV-induced tumorigenesis and inflammation, and metabolic reprogramming in KSHV infection and KSHV-transformed cells.

Similar articles

See all similar articles

Cited by 1 article

MeSH terms

Supplementary concepts