The Role of Calcium-Permeable AMPARs in Long-Term Potentiation at Principal Neurons in the Rodent Hippocampus

Front Synaptic Neurosci. 2018 Nov 22:10:42. doi: 10.3389/fnsyn.2018.00042. eCollection 2018.


Long-term potentiation (LTP) at hippocampal CA1 synapses is classically triggered by the synaptic activation of NMDA receptors (NMDARs). More recently, it has been shown that calcium-permeable (CP) AMPA receptors (AMPARs) can also trigger synaptic plasticity at these synapses. Here, we review this literature with a focus on recent evidence that CP-AMPARs are critical for the induction of the protein kinase A (PKA)- and protein synthesis-dependent component of LTP.

Keywords: NMDA receptor; PKA; calcium-permeable AMPA receptor; hippocampus; long-term potentiation.

Publication types

  • Review