CD30+ T-cell lymphoproliferative disorders

Chin Clin Oncol. 2019 Feb;8(1):4. doi: 10.21037/cco.2018.09.06. Epub 2018 Oct 11.


The term "CD30+ T-cell lymphoproliferative disorders" describes a group of diverse diseases of the skin, subcutaneous tissues and mucosa that range from lesions requiring clinical observation to those necessitating systemic cytotoxic chemotherapy. Careful consideration of both clinical and histopathologic presentation is needed for appropriate diagnosis and treatment. This review will present the current classification of these disorders and potential treatment paradigms. Primary cutaneous CD30+ T-cell lymphoproliferative disorders, breast-implant associated anaplastic large-cell lymphoma and mucosal entities will be discussed.

Keywords: Lymphomatoid papulosis (LyP); breast implant associated anaplastic large cell lymphoma; primary cutaneous anaplastic large cell lymphoma.

Publication types

  • Review

MeSH terms

  • Humans
  • Ki-1 Antigen / metabolism*
  • Lymphoproliferative Disorders / genetics*
  • Lymphoproliferative Disorders / pathology
  • T-Lymphocytes / metabolism*


  • Ki-1 Antigen