Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 52 (1), 42-46

Cellular Senescence in Cancer


Cellular Senescence in Cancer

Young Hwa Kim et al. BMB Rep.


Cellular senescence, a process of cell proliferation arrest in response to various stressors, has been considered to be important factor in age-related disease. Identification of senescent cells in tissues is limited and the role of senescent cells is poorly understood. Recently however, several studies showed the characterization of senescent cells in various pathologic conditions and the role of senescent cells in disease progression is becoming important. Senescent cells are growth-arrested cells, however, the senescence associated secretory phenotype (SASP) of senescent cells could modify the tissues' microenvironment. Here, we discuss the progress and understanding of the role of senescent cells in tissues of pathologic conditions and discuss the development of new therapeutic paradigms, such as senescent cells-targeted therapy. [BMB Reports 2019; 52(1): 42-46].

Conflict of interest statement


The authors have no conflicting interests.


Fig. 1
Fig. 1
Schematic representation of the role of senescent cells in tumors. Senescent cells express SASP and are involved in interactions with the tissue microenvironment, including extracellular matrix (ECM) degradation, immune cells infiltration, and cancer invasion.

Similar articles

See all similar articles

Cited by 2 PubMed Central articles


    1. Hayflick L, Moorhead PS. The serial cultivation of human diploid cell strains. Exp Cell Res. 1961;25:585–621. doi: 10.1016/0014-4827(61)90192-6. - DOI - PubMed
    1. Herbert B, Pitts AE, Baker SI, et al. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci U S A. 1999;96:14276–14281. doi: 10.1073/pnas.96.25.14276. - DOI - PMC - PubMed
    1. Baird DM, Rowson J, Wynford-Thomas D, Kipling D. Extensive allelic variation and ultrashort telomeres in senescent human cells. Nat Genet. 2003;33:203–207. doi: 10.1038/ng1084. - DOI - PubMed
    1. Baerlocher GM, Mak J, Roth A, Rice KS, Lansdorp PM. Telomere shortening in leukocyte subpopulations from baboons. J Leukoc Biol. 2003;73:289–296. doi: 10.1189/jlb.0702361. - DOI - PubMed
    1. Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153:1194–1217. doi: 10.1016/j.cell.2013.05.039. - DOI - PMC - PubMed