In healthy adults, resistant maltodextrin produces a greater change in fecal bifidobacteria counts and increases stool wet weight: a double-blind, randomized, controlled crossover study

Nutr Res. 2018 Dec;60:33-42. doi: 10.1016/j.nutres.2018.09.007. Epub 2018 Sep 21.

Abstract

Dietary fiber stimulates the growth of potentially beneficial bacteria (eg, bifidobacteria), yet most Americans do not meet daily fiber recommendations. Resistant maltodextrin (RMD), a fermentable functional fiber, may help individuals meet total fiber recommendations and potentially increase bifidobacteria. It was hypothesized that fecal bifidobacteria counts/ng fecal DNA would increase after adding 25 g RMD to inadequate fiber diets of healthy adults. In this double-blind, controlled crossover study, 51 participants (26.3 ± 6.8 years, mean ± SD) were randomized to consume 0, 15, and 25 g RMD daily for 3 weeks followed by a 2-week washout. Participants collected all stools for 2 days at weeks 0 and 3 of each intervention for stool wet weight (WW) measurements and fecal bifidobacteria counts. Weekly 24-hour dietary recalls assessed total fiber intake. Only 25 g RMD resulted in a change (final minus baseline) in bifidobacteria that was significant compared with 0 g (0.17 ± 0.09 vs -0.17 ± 0.09 log10[counts], respectively, mean ± SEM, P = .008). Stool WW increased only with 25 g (150 ± 11 vs baseline 121±11 g/d; P = .011). Mean daily total fiber intake (including RMD) was significantly higher (both P< .001) with 15 g (17.8 ± 0.6 g/1000 kcal or 4184 kJ) and 25 g (25.3 ± 1.1 g/1000 kcal) compared with 0 g RMD (8.4±0.4 g/1000 kcal). Mean daily total fiber intakes exceeded recommendations (14 g/1000 kcal) with 15 and 25 g of RMD, and 25 g RMD increased fecal bifidobacteria counts and stool WW, suggesting health benefits from increasing total fiber intake.

Keywords: Bifidobacteria; Gastrointestinal function; Healthy adults; Resistant maltodextrin; Stool wet weight.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Bifidobacterium / drug effects*
  • Bifidobacterium / growth & development
  • Cross-Over Studies
  • Defecation / drug effects*
  • Diet
  • Dietary Fiber / administration & dosage
  • Dietary Fiber / pharmacology*
  • Double-Blind Method
  • Feces* / microbiology
  • Female
  • Fermentation
  • Gastrointestinal Microbiome / drug effects*
  • Humans
  • Intestines / drug effects*
  • Intestines / microbiology
  • Male
  • Polysaccharides / administration & dosage
  • Polysaccharides / pharmacology*
  • Reference Values
  • Starch
  • Young Adult

Substances

  • Dietary Fiber
  • Polysaccharides
  • maltodextrin
  • Starch