Taiwan consensus statement on the management of chronic hepatitis B

J Formos Med Assoc. 2019 Jan;118(1 Pt 1):7-38. doi: 10.1016/j.jfma.2018.11.008. Epub 2018 Dec 6.


The experts of Taiwan Association for the Study of Liver (TASL) have actively participated and led the guidelines on hepatitis B virus (HBV) management by Asian Pacific Association for the Study of Liver (APASL) which is the first international association for the study of liver to publish the statement on HBV management before. However, there are more and more new data on the natural history and treatment of HBV infection in the past decade. These include new application of an old biomarker (quantitative HBsAg), clinical significance of HBV genotype and naturally occurring mutations, the role of non-invasive examination in evaluating severity of hepatic fibrosis, clinical significance of outcome calculators, new drug or new combination strategies towards more effective therapy and organ transplantation including liver and non-liver transplantation. It is time to publish the guidelines on HBV management of Taiwan. Hence, TASL have conducted an expert meeting to review, to discuss and to debate the relevant literatures, followed by draft the manuscript of HBV management guidelines and recommendations. The guidelines include general management, indications for fibrosis assessment, time to start or stop drug therapy, choice of drug to initiate therapy, when and how to monitor the patients during and after stopping drug therapy. Recommendations on the therapy of patients in special circumstances, including women in childbearing age, patients with antiviral drug resistance, concurrent viral infection, hepatic decompensation, patient receiving immune suppression or chemotherapy and patients in the setting of liver transplantation and hepatocellular carcinoma, are also included.

Keywords: Chronic hepatitis B; Entecavir; Pegylated interferon alfa; Tenofovir alafenamide; Tenofovir disoproxil fumarate.

MeSH terms

  • Antiviral Agents / adverse effects
  • Antiviral Agents / therapeutic use
  • Carcinoma, Hepatocellular / prevention & control*
  • Carcinoma, Hepatocellular / virology
  • Consensus
  • Disease Management
  • Disease Progression
  • Female
  • Guanine / analogs & derivatives
  • Guanine / therapeutic use
  • HIV Infections / drug therapy
  • Hepatitis B Surface Antigens / blood
  • Hepatitis B Vaccines / therapeutic use
  • Hepatitis B virus / drug effects
  • Hepatitis B, Chronic / complications
  • Hepatitis B, Chronic / diagnosis
  • Hepatitis B, Chronic / drug therapy*
  • Humans
  • Immunization Programs
  • Interferon-alpha / adverse effects
  • Interferon-alpha / therapeutic use
  • Liver Cirrhosis / prevention & control*
  • Liver Cirrhosis / virology
  • Liver Neoplasms / prevention & control*
  • Liver Neoplasms / virology
  • Male
  • Pregnancy
  • Societies, Medical
  • Taiwan
  • Viral Load


  • Antiviral Agents
  • Hepatitis B Surface Antigens
  • Hepatitis B Vaccines
  • Interferon-alpha
  • entecavir
  • Guanine