Structural Insights into the Mechanism of Dynamin Superfamily Proteins

Trends Cell Biol. 2019 Mar;29(3):257-273. doi: 10.1016/j.tcb.2018.11.003. Epub 2018 Dec 5.


Dynamin superfamily proteins (DSPs) mediate membrane fission and fusion necessary for endocytosis, organelle biogenesis and maintenance, as well as for bacterial cytokinesis. They also function in the innate immune response to pathogens and in organizing the cytoskeleton. In this review, we summarize the current understanding of the molecular mechanism of DSPs, with emphasis on the structural basis of function. Studies from the past decade on the structure and mechanism of DSPs enable comparative analysis of shared mechanisms and unique features of this protein family.

Keywords: dynamin; endocytosis; innate immunity; membrane fission; membrane fusion; mitochondria.

Publication types

  • Research Support, N.I.H., Intramural
  • Review

MeSH terms

  • Animals
  • Dynamins / chemistry*
  • Dynamins / classification
  • Dynamins / metabolism*
  • Humans
  • Protein Conformation


  • Dynamins