Positive and negative cycles in Boolean networks

Adrien Richard

doi:10.1016/j.jtbi.2018.11.028

Positive and negative cycles in Boolean networks

J Theor Biol. 2019 Feb 21:463:67-76. doi: 10.1016/j.jtbi.2018.11.028. Epub 2018 Dec 5.

Author

Adrien Richard¹

Affiliation

¹ Laboratoire I3S, UMR CNRS 7271, Université Côte d'Azur, France; CMM, UMI CNRS 2807, Universidad de Chile, Chile. Electronic address: richard@unice.fr.

PMID: 30528341
DOI: 10.1016/j.jtbi.2018.11.028

Abstract

We review and discuss some results about the influence of positive and negative feedback cycles in asynchronous Boolean networks. These results merge several ideas of Thomas: positive and negative feedback cycles have been largely emphasized by Thomas, through the so called Thomas' rules, and asynchronous Boolean networks have been introduced by Thomas as a model for the dynamics of gene networks, which is nowadays very popular.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Feedback*
Gene Regulatory Networks*
Humans
Models, Biological*