Measurement equivalence of the short-form Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-16)

Epilepsy Behav. 2019 Jan;90:142-147. doi: 10.1016/j.yebeh.2018.11.024. Epub 2018 Dec 7.


Objective: The aim of this study was to assess measurement equivalence in the 16-item short-form Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-16) across age, sex, and time in a sample of children with newly diagnosed epilepsy.

Methods: Data came from 373 children participating in the Health-related Quality of Life in Children with Epilepsy Study (HERQULES), a multicenter prospective cohort study. Measurement equivalence was assessed using multigroup confirmatory factor analysis methods. Comparison groups were stratified by age (4-7 years vs. 8-12 years), sex (male vs. female), and time (at diagnosis vs. 24 months postdiagnosis).

Results: The QOLCE-16 demonstrated measurement equivalence at the level of strict invariance for each comparison group tested - age: χ2 (3, 274) = 429.6, p < 0.001; comparative fit index (CFI) = 0.985; root mean square error of approximation (RMSEA) = 0.056 (0.046, 0.066); sex: χ2 (3, 271) = 430.5, p < 0.001; CFI = 0.984; RMSEA = 0.057 (0.047, 0.067); and time: χ2 (3, 269) = 566.4, p < 0.001; CFI = 0.985; RMSEA = 0.059 (0.052, 0.066).

Significance: The findings provide support for the robust psychometric profile of the QOLCE-16 as a reliable and valid measure of health-related quality of life for children with epilepsy. Demonstrating good properties and a multidimensional structure, the QOLCE-16 is an appropriate short measure for both clinicians and researchers wanting to obtain health-related quality of life information on children with epilepsy.

Keywords: Factor analysis; Health-related quality of life; Measurement equivalence; Pediatric epilepsy; Validity.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Child, Preschool
  • Cohort Studies
  • Epilepsy / diagnosis*
  • Epilepsy / psychology*
  • Factor Analysis, Statistical
  • Female
  • Humans
  • Male
  • Prospective Studies
  • Psychometrics
  • Quality of Life / psychology*
  • Reproducibility of Results
  • Surveys and Questionnaires / standards*