Peroxisome biogenesis, membrane contact sites, and quality control

EMBO Rep. 2019 Jan;20(1):e46864. doi: 10.15252/embr.201846864. Epub 2018 Dec 10.


Peroxisomes are conserved organelles of eukaryotic cells with important roles in cellular metabolism, human health, redox homeostasis, as well as intracellular metabolite transfer and signaling. We review here the current status of the different co-existing modes of biogenesis of peroxisomal membrane proteins demonstrating the fascinating adaptability in their targeting and sorting pathways. While earlier studies focused on peroxisomes as autonomous organelles, the necessity of the ER and potentially even mitochondria as sources of peroxisomal membrane proteins and lipids has come to light in recent years. Additionally, the intimate physical juxtaposition of peroxisomes with other organelles has transitioned from being viewed as random encounters to a growing appreciation of the expanding roles of such inter-organellar membrane contact sites in metabolic and regulatory functions. Peroxisomal quality control mechanisms have also come of age with a variety of mechanisms operating both during biogenesis and in the cellular response to environmental cues.

Keywords: de novo peroxisome biogenesis; peroxisomal membrane contact sites; peroxisomal membrane protein biogenesis; peroxisome growth and division; peroxisome quality control.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Endoplasmic Reticulum / genetics*
  • Endoplasmic Reticulum / metabolism
  • Eukaryotic Cells / metabolism
  • Homeostasis / genetics
  • Humans
  • Membrane Proteins / biosynthesis*
  • Membrane Proteins / genetics
  • Metabolic Networks and Pathways / genetics
  • Mitochondria / genetics*
  • Mitochondria / metabolism
  • Mitochondrial Membranes / metabolism
  • Oxidation-Reduction
  • Peroxisomes / genetics*
  • Peroxisomes / metabolism


  • Membrane Proteins