Cancer researchers seek to harness mysterious DNA 'super-enhancers'

Nature. 2018 Dec;564(7735):173-174. doi: 10.1038/d41586-018-07602-8.
No abstract available

Keywords: Drug discovery; Epigenetics; Genetics; Medical research.

Publication types

  • News

MeSH terms

  • Benzoates / pharmacology
  • Benzoates / therapeutic use
  • Cell Differentiation / drug effects
  • Cell Differentiation / genetics
  • Clinical Trials as Topic
  • DNA, Neoplasm / drug effects
  • DNA, Neoplasm / genetics*
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / drug effects
  • Embryonic Stem Cells / metabolism
  • Enhancer Elements, Genetic / drug effects
  • Enhancer Elements, Genetic / genetics*
  • Gene Expression Regulation, Neoplastic / drug effects
  • Gene Expression Regulation, Neoplastic / genetics*
  • Humans
  • Leukemia, Myeloid, Acute / drug therapy
  • Leukemia, Myeloid, Acute / genetics
  • Neoplasms / drug therapy
  • Neoplasms / genetics*
  • Neoplasms / pathology
  • Tetrahydronaphthalenes / pharmacology
  • Tetrahydronaphthalenes / therapeutic use
  • Uncertainty*

Substances

  • Benzoates
  • DNA, Neoplasm
  • Tetrahydronaphthalenes
  • tamibarotene