Electron-tracking Compton camera imaging of technetium-95m

Yuichi Hatsukawa; Takehito Hayakawa; Kazuaki Tsukada; Kazuyuki Hashimoto; Tetsuya Sato; Masato Asai; Atsushi Toyoshima; Toru Tanimori; Shinya Sonoda; Shigeto Kabuki; Hiroyuki Kimura; Atsushi Takada; Tetsuya Mizumoto; Seiya Takaki

doi:10.1371/journal.pone.0208909

Electron-tracking Compton camera imaging of technetium-95m

PLoS One. 2018 Dec 10;13(12):e0208909. doi: 10.1371/journal.pone.0208909. eCollection 2018.

Affiliations

¹ National Institutes for Quantum and Radiological Science and Technology (QST), Tokai, Ibaraki, Japan.
² Japan Atomic Energy Agency, Tokai, Ibaraki, Japan.
³ Kyoto University, Kyoto, Japan.
⁴ Tokai University, Kanagawa, Japan.
⁵ Kyoto Pharmaceutical University, Kyoto, Japan.

Abstract

Imaging was conducted using an electron tracking-Compton camera (ETCC), which measures γ-rays with energies in the range of 200-900 keV from 95mTc. 95mTc was produced by the 95Mo(p, n)95mTc reaction on a 95Mo-enriched target. A method for recycling 95Mo-enriched molybdenum trioxide was employed, and the recycled yield of 95Mo was 70%-90%. Images were obtained with the gate of three energies. The results showed that the spatial resolution increases with increasing γ-ray energy, and suggested that the ETCC with high-energy γ-ray emitters such as 95mTc is useful for the medical imaging of deep tissue and organs in the human body.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Diagnostic Imaging / methods*
Diagnostic Imaging / trends
Electrons
Gamma Cameras*
Gamma Rays
Humans
Molybdenum / chemistry
Monte Carlo Method
Oxides / chemistry
Phantoms, Imaging / trends*
Photons
Radioisotopes / chemistry
Scattering, Radiation
Technetium / chemistry*

Substances

Oxides
Radioisotopes
molybdenum trioxide
Technetium
Molybdenum

Grants and funding

Funding was provided by Japan Society for the Promotion of Science Kakenhi-JPK1605025 to YH. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.