Diagnosis of penicillin allergy: a MOFs-based composite hydrogel for detecting β-lactamase in serum

Chem Commun (Camb). 2018 Dec 20;55(2):241-244. doi: 10.1039/c8cc08245f.

Abstract

An as-synthesized MOFs-based hydrogel exhibits high sensitivity for β-lactamase through an "ON-OFF-OFF-ON" luminescence trigger. It allows achieving an unprecedented strategy for the judgement of penicillin allergy via luminescence detection of β-lactamase in serum.

MeSH terms

  • Alginates / chemistry
  • Drug Hypersensitivity / diagnosis*
  • Drug Hypersensitivity / etiology
  • Europium / chemistry
  • Humans
  • Hydrogels / chemical synthesis
  • Hydrogels / chemistry*
  • Hydrogels / radiation effects
  • Iron / chemistry
  • Limit of Detection
  • Luminescent Agents / chemical synthesis
  • Luminescent Agents / chemistry*
  • Luminescent Agents / radiation effects
  • Luminescent Measurements / methods
  • Metal-Organic Frameworks / chemical synthesis
  • Metal-Organic Frameworks / chemistry*
  • Metal-Organic Frameworks / radiation effects
  • Penicillamine / chemical synthesis
  • Penicillamine / chemistry
  • Penicillins / adverse effects*
  • Penicillins / chemistry
  • beta-Lactamases / blood*
  • beta-Lactamases / chemistry

Substances

  • Alginates
  • Hydrogels
  • Luminescent Agents
  • Metal-Organic Frameworks
  • Penicillins
  • Europium
  • Iron
  • beta-Lactamases
  • Penicillamine