Cobalt-catalyzed cross-dehydrogenative coupling between N-(2-pyridyl) and free indoles for the synthesis of unsymmetrical 2,2'-biindoles

Ting Li; Yuhan Yang; Bo Li; Ping Yang

doi:10.1039/c8cc07659f

Cobalt-catalyzed cross-dehydrogenative coupling between N-(2-pyridyl) and free indoles for the synthesis of unsymmetrical 2,2'-biindoles

Chem Commun (Camb). 2019 Jan 2;55(3):353-356. doi: 10.1039/c8cc07659f.

Authors

Ting Li¹, Yuhan Yang, Bo Li, Ping Yang

Affiliation

¹ College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan 473061, P. R. China. chemlt2015@nynu.edu.cn.

PMID: 30534712
DOI: 10.1039/c8cc07659f

Abstract

Cobalt-catalyzed cross-dehydrogenative coupling of N-(2-pyridyl) indoles with free indoles for the construction of unsymmetrical 2,2'-biindoles with excellent regioselectivity is developed. The broader substrate scope as well as the removable directing group of this strategy allows the synthesis of unsymmetrical 2,2'-biindoles to be accessible in organic synthesis.