The role of Eomes in human CD4 T cell differentiation: A question of context

Eur J Immunol. 2019 Jan;49(1):38-41. doi: 10.1002/eji.201848000.


Eomesodermin (Eomes) is a transcription factor (TF) of the T-box family closely related to T-bet known for its role in CD8 T cell and natural killer cell differentiation. However, the role of Eomes in CD4 T-cell differentiation is less well appreciated. In this issue of the European Journal of Immunology [Eur. J. Immunol. 2019. 49: 79-95] Mazzoni et al. and [Eur. J. Immunol. 2019. 49: 96-111] Gruarin et al. studied the role of Eomes in human CD4 T-cell differentiation. Mazzoni et al. showed that Eomes plays a key role in helper T cell (Th) plasticity by favoring the phenotype shift of Th17 cells toward non-classic Th1 cells; while Gruarin et al. proposed Eomes as a lineage-defining TF for human IL-10 and IFN-γ co-producing regulatory T-cells (Tr1 cells). Both studies show that Eomes drives IFN-γ secretion and stamps a "cytotoxic" signature, while it also represses Th17 features. However, additional signals including the cytokine milieu may further influence the fate of Eomes+ CD4 T cells. A common feature of Eomes+ CD4 T cells appears to be their accumulation in inflamed tissues in patients with chronic inflammatory disorders. Whether Eomes favors expression of the proinflammatory cytokines or on the contrary, promotes the anti-inflammatory cytokines, remains a matter of debate.

Keywords: CD4 T cells; EOMES; Regulatory T cells; Th1; Th17.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • CD4-Positive T-Lymphocytes
  • Cell Differentiation
  • Humans
  • Inflammation
  • Interferon-gamma
  • T-Box Domain Proteins
  • Th1 Cells*
  • Th17 Cells*


  • EOMES protein, human
  • T-Box Domain Proteins
  • Interferon-gamma