Targeting Peptide-Based Probes for Molecular Imaging and Diagnosis

doi:10.1002/adma.201804827

Review

. 2019 Nov;31(45):e1804827.

doi: 10.1002/adma.201804827. Epub 2018 Dec 7.

Targeting Peptide-Based Probes for Molecular Imaging and Diagnosis

Weizhi Wang¹, Zhiyuan Hu^{1

2

3}

Affiliations

¹ CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
² Sino-Danish College, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
³ Centre for Neuroscience Research, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350108, Fujian, P. R. China.

PMID: 30537222
DOI: 10.1002/adma.201804827

Review

Targeting Peptide-Based Probes for Molecular Imaging and Diagnosis

Weizhi Wang et al. Adv Mater. 2019 Nov.

. 2019 Nov;31(45):e1804827.

doi: 10.1002/adma.201804827. Epub 2018 Dec 7.

Authors

Weizhi Wang¹, Zhiyuan Hu^{1

2

3}

Affiliations

¹ CAS Key Laboratory of Standardization and Measurement for Nanotechnology, CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, 100190, P. R. China.
² Sino-Danish College, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
³ Centre for Neuroscience Research, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, 350108, Fujian, P. R. China.

PMID: 30537222
DOI: 10.1002/adma.201804827

Abstract

A series of novel peptide-based molecular probes for different biomarkers is highlighted herein. These probes can provide targeted recognition with high affinity, high specificity, high penetration, and rapid excretion ability. These sensitive peptides can achieve rapid and specific detection when they are conjugated with imaging moieties or are formed into nanoprobes, which can be adapted for in vivo molecular imaging in targeted diagnosis and therapy.

Keywords: diagnosis; imaging; peptides; probes; targeted recognition.

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[1] D. S. Wishart, Nat. Rev. Drug Discovery 2016, 15, 473.

[2] D. S. Wishart, Nat. Rev. Drug Discovery 2016, 15, 473.

[3] M. Gao, F. Yu, C. Lv, J. Choo, L. Chen, Chem. Soc. Rev. 2017, 46, 2237.

[4] M. Gao, F. Yu, C. Lv, J. Choo, L. Chen, Chem. Soc. Rev. 2017, 46, 2237.

[5] N. A. Rizvi, M. D. Hellmann, A. Snyder, P. Kvistborg, V. Makarov, J. J. Havel, W. Lee, J. Yuan, P. Wong, T. S. Ho, M. L. Miller, N. Rekhtman, A. L. Moreira, F. Ibrahim, C. Bruggeman, B. Gasmi, R. Zappasodi, Y. Maeda, C. Sander, E. B. Garon, T. Merghoub, J. D. Wolchok, T. N. Schumacher, T. A. Chan, Science 2015, 348, 124.

[6] N. A. Rizvi, M. D. Hellmann, A. Snyder, P. Kvistborg, V. Makarov, J. J. Havel, W. Lee, J. Yuan, P. Wong, T. S. Ho, M. L. Miller, N. Rekhtman, A. L. Moreira, F. Ibrahim, C. Bruggeman, B. Gasmi, R. Zappasodi, Y. Maeda, C. Sander, E. B. Garon, T. Merghoub, J. D. Wolchok, T. N. Schumacher, T. A. Chan, Science 2015, 348, 124.

[7] C. L. Charron, J. L. Hickey, T. K. Nsiama, D. R. Cruickshank, W. L. Turnbull, L. G. Luyt, Nat. Prod. Rep. 2016, 33, 761.

[8] C. L. Charron, J. L. Hickey, T. K. Nsiama, D. R. Cruickshank, W. L. Turnbull, L. G. Luyt, Nat. Prod. Rep. 2016, 33, 761.

[9] a) C. G. Pappas, R. Shafi, I. R. Sasselli, H. Siccardi, T. Wang, V. Narang, R. Abzalimov, N. Wijerathne, R. V. Ulijn, Nat. Nanotechnol. 2016, 11, 960;

[10] a) C. G. Pappas, R. Shafi, I. R. Sasselli, H. Siccardi, T. Wang, V. Narang, R. Abzalimov, N. Wijerathne, R. V. Ulijn, Nat. Nanotechnol. 2016, 11, 960;

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Targeting Peptide-Based Probes for Molecular Imaging and Diagnosis

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Targeting Peptide-Based Probes for Molecular Imaging and Diagnosis

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