Human herpesvirus-6 (HHV-6, HBLV) in sarcoidosis and lymphoproliferative disorders

P Biberfeld; A L Petrén; A Eklund; C Lindemalm; T Barkhem; M Ekman; D Ablashi; Z Salahuddin

doi:10.1016/0166-0934(88)90051-1

Human herpesvirus-6 (HHV-6, HBLV) in sarcoidosis and lymphoproliferative disorders

J Virol Methods. 1988 Sep;21(1-4):49-59. doi: 10.1016/0166-0934(88)90051-1.

Authors

P Biberfeld¹, A L Petrén, A Eklund, C Lindemalm, T Barkhem, M Ekman, D Ablashi, Z Salahuddin

Affiliation

¹ Department of Pathology, Karolinska Institute, Stockholm, Sweden.

PMID: 3053745
DOI: 10.1016/0166-0934(88)90051-1

Abstract

Serologic studies were done to estimate the antibody prevalence against human herpesvirus 6 (HHV-6) in patients with malignant lymphomas, Sjögren's syndrome and sarcoidosis. Serologic studies showed IgG antibody titers against HHV-6 in up to 41% of patients with sarcoidosis, 50-70% with malignant lymphomas and in 36% with Sjögren's syndrome. In situ hybridization on lymph node biopsies was positive for HHV-6 genome in 1 out of 5 sarcoidosis lymph nodes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Viral / analysis*
Fluorescent Antibody Technique
Herpesviridae / immunology*
Herpesviridae / ultrastructure
Humans
Immunoglobulin G / analysis
Immunohistochemistry
Lymphoma / immunology*
Lymphoma / microbiology
Microscopy, Electron
Nucleic Acid Hybridization
Sarcoidosis / immunology*
Sarcoidosis / microbiology
Sjogren's Syndrome / immunology*
Sjogren's Syndrome / microbiology

Substances

Antibodies, Viral
Immunoglobulin G