Glucocorticoid Resistance in Acute Lymphoblastic Leukemia: BIM Finally

Cancer Cell. 2018 Dec 10;34(6):869-871. doi: 10.1016/j.ccell.2018.11.011.


Glucocorticoid resistance represents a major challenge in treating acute lymphoblastic leukemia. In this issue of Cancer Cell, Jing and colleagues show epigenetic deregulation of glucocorticoid-induced BIM activation in glucocorticoid-resistant leukemia cells, and restore glucocorticoid-receptor-induced BIM upregulation with DNA demethylating agents to effectively enhance glucocorticoid response.

Publication types

  • Comment

MeSH terms

  • Bcl-2-Like Protein 11
  • Chromatin
  • Dexamethasone
  • Glucocorticoids*
  • Humans
  • Lymphocytes
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma*
  • Receptors, Glucocorticoid / genetics


  • Bcl-2-Like Protein 11
  • Chromatin
  • Glucocorticoids
  • Receptors, Glucocorticoid
  • Dexamethasone