Natural products: Potential therapeutic agents in multiple sclerosis

Int Immunopharmacol. 2019 Feb:67:87-97. doi: 10.1016/j.intimp.2018.11.036. Epub 2018 Dec 8.

Abstract

Multiple sclerosis is an autoimmune neurodegenerative disease, which usually caused by inflammation, demyelination, and axonal injury. The currently available medications for multiple sclerosis do not directly promote myelin sheath repair. Therefore, many researches have attempted to achieve better therapeutic effects through promoting remyelination. Natural products not only alleviate clinical symptoms, but also have the unique advantages of protecting and repairing effects on nervous system. We here present a systematic review on published papers about treating multiple sclerosis by natural products, aiming to provide comprehensive information on natural products in the treatment of multiple sclerosis.

Keywords: Anti-inflammatory; Immune regulation; Multiple sclerosis; Natural products; Nervous system repairing; Neuroprotection.

Publication types

  • Systematic Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / therapeutic use*
  • Autoimmunity
  • Biological Products / therapeutic use*
  • Humans
  • Inflammation / therapy*
  • Multiple Sclerosis / therapy*
  • Myelin Sheath / physiology*
  • Nervous System / drug effects*
  • Neuroprotective Agents / therapeutic use*

Substances

  • Anti-Inflammatory Agents
  • Biological Products
  • Neuroprotective Agents