Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke

Liang Zhao; Qiutang Xiong; Creed M Stary; Omer Kamal Mahgoub; Yingze Ye; Lijuan Gu; Xiaoxing Xiong; Shengmei Zhu

doi:10.1186/s12974-018-1382-3

Bidirectional gut-brain-microbiota axis as a potential link between inflammatory bowel disease and ischemic stroke

J Neuroinflammation. 2018 Dec 11;15(1):339. doi: 10.1186/s12974-018-1382-3.

Authors

Liang Zhao¹, Qiutang Xiong², Creed M Stary³, Omer Kamal Mahgoub⁴, Yingze Ye⁴, Lijuan Gu⁴, Xiaoxing Xiong^{5

6}, Shengmei Zhu⁷

Affiliations

¹ Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China.
² Diabetes Research Center, Renmin Hospital of Wuhan University, Wuhan, China.
³ Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA, 94305, USA.
⁴ Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China.
⁵ Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China. xiaoxingxiong@whu.edu.cn.
⁶ Department of Neurosurgery, Renmin Hospital of Wuhan University, 99 Zhang Zhidong Rd, Wuhan, 430060, Hubei, China. xiaoxingxiong@whu.edu.cn.
⁷ Department of Anesthesiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang, China. smzhu20088@zju.edu.cn.

Abstract

Emerging evidence suggests that gut-brain-microbiota axis (GBMAx) may play a pivotal role linking gastrointestinal and neuronal disease. In this review, we summarize the latest advances in studies of GBMAx in inflammatory bowel disease (IBD) and ischemic stroke. A more thorough understanding of the GBMAx could advance our knowledge about the pathophysiology of IBD and ischemic stroke and help to identify novel therapeutic targets via modulation of the GBMAx.

Keywords: Adrenocorticotropic hormone; Gut-brain-microbiota axis; Inflammatory; Inflammatory bowel disease; Ischemic stroke.

Publication types

Review

MeSH terms

Animals
Brain Ischemia / microbiology*
Brain Ischemia / physiopathology*
Gastrointestinal Microbiome / physiology*
Humans
Inflammatory Bowel Diseases / microbiology*
Inflammatory Bowel Diseases / physiopathology*

Abstract

Publication types

MeSH terms

Grants and funding