Hormonal regulation of core clock gene expression in skeletal muscle following acute aerobic exercise

Biochem Biophys Res Commun. 2019 Jan 15;508(3):871-876. doi: 10.1016/j.bbrc.2018.12.034. Epub 2018 Dec 8.


Exercise increases skeletal muscle health in part by altering the types of genes that are transcribed. Previous work suggested that glucocorticoids signal through the protein Regulated in Development and DNA Damage 1 (REDD1) to regulate gene expression following acute aerobic exercise. The present study shows that expression of the core clock gene, Period1, is among those modulated by the glucocorticoid-REDD1 signaling pathway in skeletal muscle. We also provide evidence that Aldosterone and Epinephrine contribute to the regulation of Period1 expression via REDD1. These data show that adrenal stress hormones signal through REDD1 to regulate skeletal muscle gene expression, specifically those of the core clock, following acute aerobic exercise.

Keywords: Aldosterone; Epinephrine; Glucocorticoids.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ARNTL Transcription Factors / genetics
  • ARNTL Transcription Factors / metabolism
  • Aldosterone / pharmacology
  • Animals
  • Cells, Cultured
  • Corticosterone / pharmacology
  • Dexamethasone / pharmacology
  • Epinephrine / pharmacology
  • Gene Expression Regulation*
  • Glucocorticoids / pharmacology*
  • Male
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Muscle Contraction
  • Muscle Fibers, Skeletal / drug effects
  • Muscle, Skeletal / metabolism*
  • Period Circadian Proteins / biosynthesis
  • Period Circadian Proteins / genetics*
  • Physical Conditioning, Animal*
  • Receptors, Glucocorticoid / metabolism
  • Transcription Factors / biosynthesis
  • Transcription Factors / genetics*
  • Transcription Factors / physiology


  • ARNTL Transcription Factors
  • Arntl protein, mouse
  • Ddit4 protein, mouse
  • Glucocorticoids
  • Per1 protein, mouse
  • Period Circadian Proteins
  • Receptors, Glucocorticoid
  • Transcription Factors
  • Aldosterone
  • Dexamethasone
  • Corticosterone
  • Epinephrine