Mediators of Inflammation - A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

doi:10.1155/2018/1061780

Review

. 2018 Nov 12:2018:1061780.

doi: 10.1155/2018/1061780. eCollection 2018.

Mediators of Inflammation - A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

Mircea Tampa^{1

2}, Madalina Irina Mitran^{1

2}, Cristina Iulia Mitran^{1

2}, Maria Isabela Sarbu², Clara Matei², Ilinca Nicolae¹, Ana Caruntu³, Sandra Milena Tocut⁴, Mircea Ioan Popa^{2

5}, Constantin Caruntu^{2

6}, Simona Roxana Georgescu^{1

2}

Affiliations

¹ "Victor Babes" Clinical Hospital for Infectious Diseases, 281 Mihai Bravu, 030303 Bucharest, Romania.
² "Carol Davila" University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania.
³ "Carol Davila" Central Military Emergency Hospital, 134 Calea Plevnei, 010825 Bucharest, Romania.
⁴ "Wolfson Medical Center", 61 Halochamim Street, 58100 Holon, Israel.
⁵ "Cantacuzino" National Medico-Military Institute for Research and Development, 103 Splaiul Independentei, 050096 Bucharest, Romania.
⁶ "Prof. N. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases, 22-24 Gr. Manolescu, Bucharest 011233, Romania.

PMID: 30539028
PMCID: PMC6260538
DOI: 10.1155/2018/1061780

Free PMC article

Review

Mediators of Inflammation - A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

Mircea Tampa et al. J Immunol Res. 2018.

Free PMC article

. 2018 Nov 12:2018:1061780.

doi: 10.1155/2018/1061780. eCollection 2018.

Authors

Affiliations

¹ "Victor Babes" Clinical Hospital for Infectious Diseases, 281 Mihai Bravu, 030303 Bucharest, Romania.
² "Carol Davila" University of Medicine and Pharmacy, 37 Dionisie Lupu, 020021 Bucharest, Romania.
³ "Carol Davila" Central Military Emergency Hospital, 134 Calea Plevnei, 010825 Bucharest, Romania.
⁴ "Wolfson Medical Center", 61 Halochamim Street, 58100 Holon, Israel.
⁵ "Cantacuzino" National Medico-Military Institute for Research and Development, 103 Splaiul Independentei, 050096 Bucharest, Romania.
⁶ "Prof. N. Paulescu" National Institute of Diabetes, Nutrition and Metabolic Diseases, 22-24 Gr. Manolescu, Bucharest 011233, Romania.

PMID: 30539028
PMCID: PMC6260538
DOI: 10.1155/2018/1061780

Abstract

Oral squamous cell carcinoma (OSCC) is the most common tumour of the oral cavity, associated with significant morbidity and mortality. It is a multifactorial condition, both genetic and environmental factors being involved in its development and progression. Its pathogenesis is not fully elucidated, but a pivotal role has been attributed to inflammation, strong evidence supporting the association between chronic inflammation and carcinogenesis. Moreover, an increasing number of studies have investigated the role of different mediators of inflammation in the early detection of OSCC. In this review, we have summarized the main markers of inflammation that could be useful in diagnosis and shed some light in OSCC pathogenesis.

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References

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1. Bulman A., Neagu M., Constantin C. Immunomics in skin cancer - improvement in diagnosis, prognosis and therapy monitoring. Current Proteomics. 2013;10(3):202–217. doi: 10.2174/1570164611310030003. - DOI - PMC - PubMed
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[1] Omura K. Current status of oral cancer treatment strategies: surgical treatments for oral squamous cell carcinoma. International Journal of Clinical Oncology. 2014;19(3):423–430. doi: 10.1007/s10147-014-0689-z. - DOI - PubMed

[2] Omura K. Current status of oral cancer treatment strategies: surgical treatments for oral squamous cell carcinoma. International Journal of Clinical Oncology. 2014;19(3):423–430. doi: 10.1007/s10147-014-0689-z. - DOI - PubMed

[3] Bulman A., Neagu M., Constantin C. Immunomics in skin cancer - improvement in diagnosis, prognosis and therapy monitoring. Current Proteomics. 2013;10(3):202–217. doi: 10.2174/1570164611310030003. - DOI - PMC - PubMed

[4] Bulman A., Neagu M., Constantin C. Immunomics in skin cancer - improvement in diagnosis, prognosis and therapy monitoring. Current Proteomics. 2013;10(3):202–217. doi: 10.2174/1570164611310030003. - DOI - PMC - PubMed

[5] Thomson P. J. Perspectives on oral squamous cell carcinoma prevention-proliferation, position, progression and prediction. Journal of Oral Pathology & Medicine. 2018;47(9):803–807. doi: 10.1111/jop.12733. - DOI - PubMed

[6] Thomson P. J. Perspectives on oral squamous cell carcinoma prevention-proliferation, position, progression and prediction. Journal of Oral Pathology & Medicine. 2018;47(9):803–807. doi: 10.1111/jop.12733. - DOI - PubMed

[7] Markopoulos A. K. Current aspects on oral squamous cell carcinoma. The Open Dentistry Journal. 2012;6(1):126–130. doi: 10.2174/1874210601206010126. - DOI - PMC - PubMed

[8] Markopoulos A. K. Current aspects on oral squamous cell carcinoma. The Open Dentistry Journal. 2012;6(1):126–130. doi: 10.2174/1874210601206010126. - DOI - PMC - PubMed

[9] Scully C., Bagan J. Oral squamous cell carcinoma overview. Oral Oncology. 2009;45(4-5):301–308. doi: 10.1016/j.oraloncology.2009.01.004. - DOI - PubMed

[10] Scully C., Bagan J. Oral squamous cell carcinoma overview. Oral Oncology. 2009;45(4-5):301–308. doi: 10.1016/j.oraloncology.2009.01.004. - DOI - PubMed

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Mediators of Inflammation - A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

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Mediators of Inflammation - A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma

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