Objective: To investigate the effect of biofeedback therapy on metabolic syndrome (MS) and the effect of different levels of job stress on the outcome. Methods: The physicians in tertiary hospitals who were diagnosed with MS from January to December, 2016 were divided into biofeedback group and health education group according to different intervention methods, and moderate group, medium group, and high group according to different levels of job stress. A 6-month intervention was implemented from May to October, 2017. A two-way factorial design was used to analyze the main effect of biofeedback on physical and biochemical parameters and the interaction of biofeedback and job stress. Results: After 6 months of intervention, the patients in both the biofeedback group and the moderate group had significantly decreased waist circumference, body mass index, systolic blood pressure (SBP) , diastolic blood pressure (DBP) , and levels of triglyceride (TG) , total cholesterol, low-density lipoprotein cholesterol (LDL-C) , and fasting plasma glucose (FPG) and a significantly increased level of high-density lipoprotein cholesterol (HDL-C) (all P<0.05) ; the patients in both the health education group and the moderate group had significantly decreased SBP, DBP, and levels of TG, LDL-C, and FPG (P<0.05) . The factorial analysis of variance showed that there was a synergistic interaction between the intervention method and job stress level in SBP, DBP, TG, HDL-C, LDL-C, and FPG among MS patients (P<0.05) . The high group had significantly more improvements in all indices compared with the medium group and the moderate group (P<0.05) . Conclusion: Biofeedback therapy can effectively improve blood pressure, blood lipids, and blood glucose in MS patients, and is more effective for patients with high job stress level.
目的： 探讨生物反馈疗法对代谢综合征（MS）患者的疗效，以及不同职业应激水平对于干预效果的影响。 方法： 于2016年1至12月，以被诊断为MS的三级医院医师作为研究对象，根据干预方式不同分为生物反馈组和健康教育组，根据MS患者职业应激程度分为适度、中度、高度3个水平。采用两因素析因设计，于2017年5至10月对患者开展为期6个月的干预，分析干预后生物反馈、职业应激水平对MS患者体格和生化指标的主效应和交互作用。 结果： 干预6个月后，生物反馈组患者腰围（WC）、体质指数（BMI）、收缩压（SBP）、舒张压（DBP）、甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、空腹血糖（FPG）水平下降，而高密度脂蛋白胆固醇（HDL-C）水平升高，差异均有统计学意义（P<0.05）；健康教育组患者SBP、DBP、TG、LDL-C、FPG水平下降，差异均有统计学意义（P<0.05）。析因设计方差分析结果显示，干预方式和职业应激水平对于MS患者SBP、DBP、TG、HDL-C、LDL-C和FPG指标存在协同交互作用（P<0.05），高度职业应激水平患者与中度、适度职业应激水平患者相比，生物反馈干预后各项指标变化幅度更大。 结论： 生物反馈疗法可有效改善MS患者的血压、血脂和血糖指标，且对高度职业应激水平患者更为有效。.
Keywords: Biofeedback; Factorial design; Job stress; Metabolic syndrome.