Impaired aortic distensibility and elevated central blood pressure in Turner Syndrome: a cardiovascular magnetic resonance study

J Cardiovasc Magn Reson. 2018 Dec 13;20(1):80. doi: 10.1186/s12968-018-0497-0.

Abstract

Background: Women with Turner Syndrome have an increased risk for aortic dissection. Arterial stiffening is a risk factor for aortic dilatation and dissection. Here we investigate if arterial stiffening can be observed in Turner Syndrome patients and is an initial step in the development of aortic dilatation and subsequent dissection.

Methods: Fifty-seven women with Turner Syndrome (48 years [29-66]) and thirty-six age- and sex-matched controls (49 years [26-68]) were included. Distensibility, blood pressure, carotid-femoral pulse wave velocity (PWV), the augmentation index (Aix) and central blood pressure were determined using cardiovascular magnetic resonance, a 24-h blood pressure measurement and applanation tonometry. Aortic distensibility was determined at three locations: ascending aorta, transverse aortic arch, and descending aorta.

Results: Mean aortic distensibility in the descending aorta was significantly lower in Turner Syndrome compared to healthy controls (P = 0.02), however, this was due to a much lower distensibility among Turner Syndrome with coarctation, while Turner Syndrome without coarctation had similar distensibility as controls. Both the mean heart rate adjusted Aix (31.4% vs. 24.4%; P = 0.02) and central diastolic blood pressure (78.8 mmHg vs. 73.7 mmHg; P = 0.02) were higher in Turner Syndrome compared to controls, and these indices correlated significantly with ambulatory night-time diastolic blood pressure. The presence of aortic coarctation (r = - 0.44, P = 0.005) and a higher central systolic blood pressure (r = - 0.34, P = 0.03), age and presence of diabetes were inversely correlated with aortic distensibility in TS.

Conclusion: Aortic wall function in the descending aorta is impaired in Turner Syndrome with lower distensibility among those with coarctation of the aorta, and among all Turner Syndrome higher Aix, and elevated central diastolic blood pressure when compared to sex- and age-matched controls.

Trial registration: The study was registered at ClinicalTrials.gov ( #NCT01678274 ) on September 3, 2012.

Keywords: Aortic dissection; Aortic distensibility; Chromosome aberrations; Hypertension; Turner Syndrome; Vascular stiffness.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aneurysm, Dissecting / diagnostic imaging*
  • Aneurysm, Dissecting / etiology
  • Aneurysm, Dissecting / physiopathology
  • Aorta / diagnostic imaging*
  • Aorta / physiopathology
  • Aortic Aneurysm / diagnostic imaging*
  • Aortic Aneurysm / etiology
  • Aortic Aneurysm / physiopathology
  • Case-Control Studies
  • Dilatation, Pathologic
  • Female
  • Humans
  • Hypertension / diagnostic imaging*
  • Hypertension / etiology
  • Hypertension / physiopathology
  • Magnetic Resonance Imaging, Cine*
  • Middle Aged
  • Predictive Value of Tests
  • Prospective Studies
  • Pulse Wave Analysis
  • Turner Syndrome / complications*
  • Turner Syndrome / diagnosis
  • Vascular Stiffness*

Associated data

  • ClinicalTrials.gov/NCT01678274