Comment on "ALK is a therapeutic target for lethal sepsis"

Sci Transl Med. 2018 Dec 12;10(471):eaar4321. doi: 10.1126/scitranslmed.aar4321.


Physiologically relevant ALK (anaplastic lymphoma kinase) expression was not detected in human and mouse monocytes and macrophages, suggesting that the effects of bioactive compounds on stimulator of interferon genes (STING) activation may not depend on ALK.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Anaplastic Lymphoma Kinase
  • Animals
  • Humans
  • Mice
  • Receptor Protein-Tyrosine Kinases*
  • Sepsis*


  • Anaplastic Lymphoma Kinase
  • Receptor Protein-Tyrosine Kinases