Redox-triggered cascade dearomative cyclizations enabled by hexafluoroisopropanol

Chem Sci. 2018 Sep 13;9(43):8253-8259. doi: 10.1039/c8sc03339k. eCollection 2018 Nov 21.

Abstract

An unprecedented cascade dearomative cyclization through hydrogen-bonding-assisted hydride transfer is realized. The aggregate effect of HFIP enables the rapid buildup of polycyclic amines directly from phenols and o-aminobenzaldehydes via a cascade dearomatization/rearomatization/dearomatization sequence. This unique transformation addressed the drawbacks of hydride transfer-involved redox-neutral reactions.