Retrovirus Restriction by TRIM5α: RINGside at a Cage Fight

Wesley I Sundquist; Owen Pornillos

doi:10.1016/j.chom.2018.11.013

Retrovirus Restriction by TRIM5α: RINGside at a Cage Fight

Cell Host Microbe. 2018 Dec 12;24(6):751-753. doi: 10.1016/j.chom.2018.11.013.

Authors

Wesley I Sundquist¹, Owen Pornillos²

Affiliations

¹ Department of Biochemistry, University of Utah, Salt Lake City, UT, USA. Electronic address: wes@biochem.utah.edu.
² Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA, USA. Electronic address: opornillos@virginia.edu.

Abstract

The restriction factor TRIM5α recognizes incoming retroviral capsids and blocks virus replication. In this issue of Cell Host & Microbe, Fletcher et al. (2018) show how the TRIM5α RING domain mediates formation of various ubiquitin conjugates that differentially regulate TRIM5α turnover, inhibition of viral reverse transcription, and innate immune activation.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Capsid
Carrier Proteins*
Retroviridae*
Ubiquitin
Virus Replication

Substances

Carrier Proteins
Ubiquitin

Abstract

Publication types

MeSH terms

Substances

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