Occurrence and fate of antibiotics and antibiotic resistance genes in typical urban water of Beijing, China

Xiaohui Liu; Guodong Zhang; Ying Liu; Shaoyong Lu; Pan Qin; Xiaochun Guo; Bin Bi; Lei Wang; Beidou Xi; Fengchang Wu; Weiliang Wang; Tingting Zhang

doi:10.1016/j.envpol.2018.12.005

Occurrence and fate of antibiotics and antibiotic resistance genes in typical urban water of Beijing, China

Environ Pollut. 2019 Mar:246:163-173. doi: 10.1016/j.envpol.2018.12.005. Epub 2018 Dec 5.

Authors

Xiaohui Liu¹, Guodong Zhang², Ying Liu³, Shaoyong Lu⁴, Pan Qin³, Xiaochun Guo³, Bin Bi³, Lei Wang³, Beidou Xi³, Fengchang Wu³, Weiliang Wang², Tingting Zhang⁵

Affiliations

¹ State Environmental Protection Scientific Observation and Research Station for Lake Dongtinghu (SEPSORSLD), National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, State Key Laboratory of Environmental Criteria an Risk Assessment, Research Centre of Lake Environment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China; School of Environment, Tsinghua University, Beijing, 100084, China.
² School of Geography and Environment, Shandong Normal University, Jinan, Shandong, 250358, China.
³ State Environmental Protection Scientific Observation and Research Station for Lake Dongtinghu (SEPSORSLD), National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, State Key Laboratory of Environmental Criteria an Risk Assessment, Research Centre of Lake Environment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China.
⁴ State Environmental Protection Scientific Observation and Research Station for Lake Dongtinghu (SEPSORSLD), National Engineering Laboratory for Lake Pollution Control and Ecological Restoration, State Key Laboratory of Environmental Criteria an Risk Assessment, Research Centre of Lake Environment, Chinese Research Academy of Environmental Sciences, Beijing, 100012, China. Electronic address: sylu@craes.org.cn.
⁵ School of Chemical Engineering, Beijing University of Chemical Technology, Beijing, 100029, China.

PMID: 30543942
DOI: 10.1016/j.envpol.2018.12.005

Abstract

The pollution of antibiotics and antibiotic resistance genes (ARGs) has been highlighted on a global scale because of their serious threats to the environment and human health. Typical urban water in cities with high population density are ideal mediums for the acquisition and spread of antibiotics and ARGs. The pollution level of a broad range of antibiotics and ARGs in hospital wastewater, groundwater and the Wenyu River, and their fates through three sewage treatment plants (STPs) were investigated in this study. The concentrations of the 11 detected antibiotics ranged from not detected (ND)-16800 ng L^-1 in diverse water samples from Beijing, and fluoroquinolones were detected at the highest concentration, especially in the hospital samples. The maximum concentrations of antibiotics in STPs and hospital were 1-3 orders of magnitude higher than those in the surface water from Wenyu River and groundwater. Good removal efficiencies by treatment processes were observed for tetracyclines and quinolones, and low removal efficiencies were observed for sulfonamides and macrolides. These results also revealed that the sulfonamide resistance genes (sul1, sul2) and macrolide resistance genes (ermB) were detected at the highest relative abundances (7.11 × 10^-2-1.18 × 10^-1) in the water bodies of Beijing. It was worth noting that sul1 abundance was the highest in groundwater samples. The relative abundance of most ARGs in STPs exhibited a declining trend in the order of influent > secondary effluents > effluent. However, the relative abundance of sul 1, sul 2 and tetC in the effluent was higher than those in the influent. The incomplete removal of antibiotics and ARGs in STPs poses a serious threat to the receiving rivers, and affects ecosystem security. Overall, our findings provide favorable support for a further investigation of the spread and risk of antibiotics and ARGs from diverse sources (e.g., STPs and hospitals) to the aquatic environment.

Keywords: ARGs; Antibiotics; Occurrence; Typical urban water.

MeSH terms

Anti-Bacterial Agents / analysis*
Beijing
Drug Resistance, Microbial / genetics*
Environmental Monitoring*
Groundwater / chemistry
Rivers / chemistry
Waste Disposal, Fluid / statistics & numerical data
Wastewater / chemistry
Water / chemistry*
Water Pollutants, Chemical / analysis*

Substances

Anti-Bacterial Agents
Waste Water
Water Pollutants, Chemical
Water