Hearing preservation after Gamma Knife radiosurgery for cerebellopontine angle meningiomas

J Neurosurg. 2018 Dec 1;129(Suppl1):38-46. doi: 10.3171/2018.7.GKS181308.


OBJECTIVEThe objective of this study was to assess hearing function after Gamma Knife treatment of cerebellopontine angle (CPA) meningiomas and assess factors affecting hearing outcome. Additionally, the authors opted to compare these results with those after Gamma Knife treatment of vestibular schwannomas (VSs), because most of the information on hearing outcome after stereotactic radiosurgery (SRS) comes from reports on VS treatment. Hearing preservation, to the best of the authors' knowledge, has never been separately addressed in studies involving Gamma Knife radiosurgery (GKRS) for CPA meningiomas.METHODSThis study included all patients who underwent a single session of GKRS between 2002 and 2014. The patients were divided into two groups. Group A included 66 patients with CPA meningiomas with serviceable hearing and tumor extension into the region centered on the internal auditory meatus. Group B included 144 patients with VSs with serviceable hearing. All patients had serviceable hearing before treatment (Gardner-Robertson [GR] Grades I and II). The median prescription dose was 12 Gy (range 10-12 Gy) in both groups. The median follow-up of groups A and B was 42 months (range 6-149 months) and 49 months (range 6-149 months), respectively.RESULTSAt the last follow-up, the tumor control rate was 97% and 94% in groups A and B, respectively. Hearing preservation was defined as maintained serviceable hearing according to GR hearing score. The hearing preservation rate was 98% and 66% and the 7-year actuarial serviceable hearing preservation rate was 75% and 56%, respectively, between both groups. In group A, the median maximum cochlear dose in the patients with stable and worsened hearing grade was 6.3 Gy and 5.5 Gy, respectively. In group B, factors affecting hearing preservation were cochlear dose ≤ 7 Gy, follow-up duration, and tumor control. The only determinant of hearing preservation between both groups was tumor type.CONCLUSIONSGKRS for CPA meningiomas provides excellent hearing preservation in addition to high tumor control rate. Hearing outcome is better with CPA meningiomas than with VSs. Further long-term prospective studies on determinants of hearing outcome after GKRS for CPA meningiomas should be conducted.

Keywords: ARE = adverse radiation event; CPA = cerebellopontine angle; FSRT = fractionated stereotactic radiotherapy; GKRS = Gamma Knife radiosurgery; GR = Gardner-Robertson; Gamma Knife; IAC = internal auditory canal; IC = intracanalicular; SRS = stereotactic radiosurgery; VS = vestibular schwannoma; cerebellopontine; hearing; meningiomas; stereotactic radiosurgery; vestibular schwannomas.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Cerebellopontine Angle
  • Female
  • Follow-Up Studies
  • Hearing Loss / etiology
  • Hearing Tests
  • Hearing*
  • Humans
  • Male
  • Meningeal Neoplasms / physiopathology
  • Meningeal Neoplasms / radiotherapy*
  • Meningioma / physiopathology
  • Meningioma / radiotherapy*
  • Middle Aged
  • Radiosurgery* / adverse effects
  • Retrospective Studies
  • Young Adult