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Meta-Analysis
, 8 (1), 277

Psychoradiological Investigations of Gray Matter Alterations in Patients With Anorexia Nervosa

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Meta-Analysis

Psychoradiological Investigations of Gray Matter Alterations in Patients With Anorexia Nervosa

Simin Zhang et al. Transl Psychiatry.

Abstract

Anorexia nervosa (AN) is a severe psychiatric disorder with high mortality. The underlying neurobiological mechanisms are not well understood, and high-resolution structural magnetic resonance brain imaging studies have given inconsistent results. Here we aimed to psychoradiologically define the most prominent and replicable abnormalities of gray matter volume (GMV) in AN patients, and to examine their relationship to demographics and clinical characteristics, by means of a new coordinate-based meta-analytic technique called seed-based d mapping (SDM). In a pooled analysis of all AN patients we identified decreased GMV in the bilateral median cingulate cortices and posterior cingulate cortices extending to the bilateral precuneus, and the supplementary motor area. In subgroup analysis we found an additional decreased GMV in the right fusiform in adult AN, and a decreased GMV in the left amygdala and left anterior cingulate cortex in AN patients without comorbidity (pure AN). Thus, the most consistent GMV alterations in AN patients are in the default mode network and the sensorimotor network. These psychoradiological findings of the brain abnormalities might underpin the neuropathophysiology in AN.

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1. Search strategy used for the inclusion of the studies considered in the current meta-analysis.
AN anorexia nervosa, VBM voxel-based morphometry
Fig. 2
Fig. 2. Regions showing reduced gray matter volume in AN patients compared with healthy controls.
L left, R right, B bilateral, Pre precuneus, PCC posterior cingulate cortex, SMA supplementary motor area, MCC median cingulate cortex
Fig. 3
Fig. 3. Regions showing reduced gray matter volume in AN-adult patients compared with healthy controls.
L left, R right, B bilateral, Pre precuneus, SMA supplementary motor area, MCC median cingulate cortex
Fig. 4
Fig. 4. Regions showing reduced gray matter volume in pure (non-comorbid) AN patients compared with healthy controls.
L left, R right, B bilateral, Pre precuneus, PCC posterior cingulate cortex, SMA supplementary motor area, MCC median cingulate cortex, ACC anterior cingulate cortex

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