Presence of both anti-contactin 1 and anti-neurofascin 140 antibodies in a case of chronic inflammatory demyelinating polyneuropathy

eNeurologicalSci. 2018 Nov 22:13:38-39. doi: 10.1016/j.ensci.2018.11.016. eCollection 2018 Dec.

Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired disorder of peripheral nerves and nerve roots. Its cause is unknown, but recently antibodies to nodal and paranodal proteins have been discovered in a small subset of CIDP patients. These contactin and neurofascin-related immune-mediated neuropathies are thought to be variants of CIDP and often respond suboptimally to standard therapy. Here, we report a patient with both anti-contactin 1 and anti-neurofascin 140 antibodies whose presentation resembled phenotypes of both CIDP variants.

Keywords: Antibodies; Chronic Inflammatory Demyelinating; Contactin 1; Immunoglobulins; Intravenous; NFASC protein human; Neuromuscular Diseases; Polyradiculoneuropathy; Proteinuria.

Publication types

  • Case Reports