Thyroid Hormone Deiodination and Action in the Gonads

Curr Opin Endocr Metab Res. 2018 Oct;2:18-23. doi: 10.1016/j.coemr.2018.01.010. Epub 2018 Feb 7.


Alterations in thyroid hormone (TH) status during developmental or adult age are associated with abnormal gonadal development and function in human and animal models. In the developing testis, aberrant levels of TH action lead to disruptions in cell proliferation and differentiation, ultimately influencing testicular size, spermatogenesis, steroidogenesis and male fertility. Recent work is increasingly identifying the systems and signaling pathways in gonadal cells that are affected by TH, as well as delineating the major factors that determine TH signaling in gonadal tissue. The TH receptor alpha, the monocarboxylate transporter 8 and the type 3 deiodinase appear to be major contributors to the timely regulation of TH action in the developing testis.

Keywords: Dio1; Dio2; Dio3; Leydig cell; Mct8; Sertoli cell; Thra; Thrb; ovary; testis; thyroid hormone; thyroid hormone deiodinase; thyroid hormone receptor; thyroid hormone transporter.