Leptotrichia trevisanii bacteremia in a woman with systemic lupus erythematosus receiving high-dose chemotherapy

BMC Infect Dis. 2018 Dec 14;18(1):661. doi: 10.1186/s12879-018-3495-9.

Abstract

Background: Leptotrichia species are aerotolerant, Gram-negative fusiform bacteria. Cases of bacteremia caused by Leptotrichia trevisanii in immunocompromised patients have been rarely reported.

Case presentation: A 33-year-old female with systemic lupus erythematosus (SLE) was admitted to the department of rheumatology with bleeding from a mucosal ulcer. One month previously, she had visited our hospital and begun to receive methotrexate therapy, but mis-dosed for nearly 1 month at home. Methotrexate toxicity resulted in a severe oral ulcer and bone marrow suppression. On day-7 of hospital admission, she developed a fever, and Gram-negative rods (Leptotrichia trevisanii) were detected in blood cultures. She was diagnosed with methotrexate poisoning followed by L. trevisanii bacteremia. After antibiotic and detoxification therapy, she recovered from bacteremia, and the oral ulcer and bone-marrow suppression improved obviously.

Conclusions: This is the first reported case of Leptotrichia trevisanii bacteremia in a SLE patient who took mis-dosed an immunosuppressant and had an oral mucosal lesion.

Keywords: Bacteremia; Leptotrichia trevisanii; SLE.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Bacteremia* / diagnosis
  • Bacteremia* / etiology
  • Female
  • Fusobacteriaceae Infections* / diagnosis
  • Fusobacteriaceae Infections* / etiology
  • Humans
  • Immunosuppressive Agents* / adverse effects
  • Immunosuppressive Agents* / therapeutic use
  • Leptotrichia*
  • Lupus Erythematosus, Systemic* / complications
  • Lupus Erythematosus, Systemic* / drug therapy
  • Methotrexate / adverse effects
  • Methotrexate / therapeutic use

Substances

  • Immunosuppressive Agents
  • Methotrexate