New Data on Vanillin-Based Isothiazolic Insecticide Synergists

Nat Prod Commun. 2017 Jan;12(1):105-106.

Abstract

By alkylation of vanillin with 4,5-dichloro-3-chloromethylisothiazole the corresponding ether was synthesized. The latter was then reacted with p-toluidine to afford the corresponding azomethine. During the bioassays of synthesized isothiazolic derivatives of vanillin in mixtures with insecticides (imidacloprid and a-cypermethrin) a strong synergetic effect was observed.

MeSH terms

  • Animals
  • Benzaldehydes / pharmacology*
  • Coleoptera
  • Insecta
  • Insecticide Resistance
  • Insecticides*
  • Larva
  • Neonicotinoids / pharmacology
  • Nitro Compounds / pharmacology
  • Pyrethrins / pharmacology
  • Thiazoles / pharmacology*
  • Toluidines / pharmacology

Substances

  • Benzaldehydes
  • Insecticides
  • Neonicotinoids
  • Nitro Compounds
  • Pyrethrins
  • Thiazoles
  • Toluidines
  • cypermethrin
  • imidacloprid
  • vanillin
  • 4-toluidine