Syngeneic, in contrast to allogeneic, mesenchymal stem cells have superior therapeutic potential following spinal cord injury

J Neuroimmunol. 2019 Mar 15:328:5-19. doi: 10.1016/j.jneuroim.2018.11.005. Epub 2018 Nov 16.


We evaluated the importance of histocompatibility of transplanted MSCs in terms of therapeutic potential. Mouse syngeneic MSCs or allogeneic MSCs were transplanted following SCI in mouse. In this study we found that syngeneic, but not allogeneic, MSCs alternatively activated macrophages resulting in a down-regulation of pro-inflammation. Syngeneic MSCs also had a general suppressive effect on the immune response as compared to allogeneic MSCs. Additionally, syngeneic, but not allogeneic, MSCs significantly enhanced the recovery of hind limb function. In this study we show that the histocompatibility of transplanted MSCs is of importance for their therapeutic potential.

Keywords: Graft survival; Hind limb function; Histocompatibility; Immune response; Mesenchymal stem cell; Neuroinflammation; Spinal cord injury.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Mesenchymal Stem Cell Transplantation / methods*
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Recovery of Function
  • Spinal Cord Injuries / immunology
  • Spinal Cord Injuries / therapy*
  • Transplantation, Homologous / methods*
  • Transplantation, Isogeneic / methods*