Associations between Maternal Exposure to Bisphenol A or Triclosan and Gestational Hypertension and Preeclampsia: The MIREC Study

Am J Perinatol. 2019 Sep;36(11):1127-1135. doi: 10.1055/s-0038-1676489. Epub 2018 Dec 14.


Background: Little is known about the association between bisphenol A (BPA) or triclosan (TCS) exposure and hypertension in pregnancy.

Objective: To investigate potential associations between maternal urinary concentrations of BPA or TCS and gestational hypertension (GH) and preeclampsia.

Study design: Among 1,909 pregnant women participating in the maternal-infant research on environmental chemicals (MIREC) study, urinary concentrations of BPA and TCS were measured in the first trimester by liquid chromatography-tandem mass spectrometry using isotope dilution. Blood pressure was measured during each trimester. Multinomial regression was performed to estimate the adjusted odds ratio (aOR) and 95% confidence intervals (CI) for the associations between these phenols and GH and preeclampsia.

Results: BPA and TCS were not associated with GH or preeclampsia. However, in multiparous women, BPA (0.50-1.30 µg/L) was associated with decreased risk of GH (aOR =0.45; 95%CI: 0.21-0.98) while among nulliparous women, TCS was associated with an increased risk of GH (3.60-32.60 µg/L; aOR = 2.58; 95% CI: 1.09-6.13 and > 32.60 µg/L: aOR = 2.74; 95% CI: 1.15-6.51).

Conclusion: BPA and TCS urinary concentrations were not associated with GH or preeclampsia; however, our results suggest an association between TCS and GH in nulliparous women. Additional studies are required to confirm our results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Air Pollutants, Occupational / adverse effects*
  • Anti-Infective Agents, Local / adverse effects*
  • Benzhydryl Compounds / adverse effects*
  • Benzhydryl Compounds / urine
  • Chromatography, Liquid
  • Female
  • Humans
  • Hypertension, Pregnancy-Induced / chemically induced*
  • Maternal Exposure
  • Middle Aged
  • Odds Ratio
  • Phenols / adverse effects*
  • Phenols / urine
  • Pre-Eclampsia / chemically induced*
  • Pregnancy
  • Pregnancy Trimester, First / urine
  • Tandem Mass Spectrometry
  • Triclosan / adverse effects*
  • Triclosan / urine
  • Young Adult


  • Air Pollutants, Occupational
  • Anti-Infective Agents, Local
  • Benzhydryl Compounds
  • Phenols
  • Triclosan
  • bisphenol A