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. 2018 Oct;29:49-55.
doi: 10.1016/j.cois.2018.05.013. Epub 2018 May 26.

Omics Approaches to Study Juvenile Hormone Synthesis

Free PMC article

Omics Approaches to Study Juvenile Hormone Synthesis

Marcela Nouzova et al. Curr Opin Insect Sci. .
Free PMC article


The juvenile hormones (JHs) are a family of insect acyclic sesquiterpenoids produced by the corpora allata (CA), a pair of endocrine glands connected to the brain. They are involved in the regulation of development, reproduction, behavior, caste determination, diapause, stress response, and numerous polyphenisms. In the post-genomics era, comprehensive analyses using functional 'omics' technologies such as transcriptomics, proteomics and metabolomics have increased our understanding of the activity of the minute CA. This review attempts to summarize some of the 'omics' studies that have contributed to further understand JH synthesis in insects, with an emphasis on our own research on the mosquito Aedes aegypti.


Figure 1.
Figure 1.. Regulation of juvenile hormone synthesis in mosquitoes.
Schematic representation of tissues and molecules (peptides and receptors) involved in the regulation of JH biosynthesis in pupa and adult mosquitoes. The activity of the CA is regulated by factors produced by the brain and ovaries in adult mosquitoes, as well as by factors from Inka cells and body wall in pupa. Allatoregulatory factors stimulate (green) or inhibit (red) JH biosynthesis through receptors in the CA. 20E and ETH increase JHAMT activity. ATC and ILP modulate JH precursor pool sizes. CC: corpora cardiaca, CA: corpora allata, 20E: 20 hydroxyecdysone, AST-C: allatostatin-C, AT: allatotropin, ILP: insulin-like peptides, R: receptor, FAL: farnesal, FA: farnesoic acid, MF: methyl farnesoate, JHAMT: juvenile hormone acid methyl transferase, JH: juvenile hormone.

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