The therapeutic potential of curcumin: A review of clinical trials

Eur J Med Chem. 2019 Feb 1;163:527-545. doi: 10.1016/j.ejmech.2018.12.016. Epub 2018 Dec 7.


Curcuma longa L., its derived extracts and even its major compound curcumin has a long history of use and doubtless effectiveness, reported through increasingly detailed in vitro, ex vivo, in vivo and even clinical trials. Regarding its biological effects, multiple health-promoting, disease-preventing and even treatment attributes has been remarkably highlighted. Clinical trials, although have increased in a progressive manner, significant disproportionalities have been stated in terms of biological effects assessment. In this sense, the present report aims to provide an extensive overview to curcumin therapeutic effects in human subjects. For that, clinical trials assessing the curcumin effect on inflammation, skin, eye, central nervous system, respiratory, cardiovascular, gastrointestinal, urogenital and metabolic disorders are here presented and discussed. A special emphasis was also given to curcumin activity on intoxications and multiple malignant diseases.

Keywords: Clinical trials; Curcuma longa L.; Curcuminoids; Pharmacological effects; Secondary metabolites.

Publication types

  • Review

MeSH terms

  • Clinical Trials as Topic*
  • Curcuma / chemistry
  • Curcumin / therapeutic use*
  • Humans
  • Inflammation / drug therapy
  • Metabolic Diseases / drug therapy


  • Curcumin