Accuracy of interferon-γ-induced protein 10 for diagnosing latent tuberculosis infection: a systematic review and meta-analysis

X Qiu; Y Tang; Y Yue; Y Zeng; W Li; Y Qu; D Mu

doi:10.1016/j.cmi.2018.12.006

Accuracy of interferon-γ-induced protein 10 for diagnosing latent tuberculosis infection: a systematic review and meta-analysis

Clin Microbiol Infect. 2019 Jun;25(6):667-672. doi: 10.1016/j.cmi.2018.12.006. Epub 2018 Dec 14.

Authors

X Qiu¹, Y Tang², Y Yue¹, Y Zeng¹, W Li¹, Y Qu¹, D Mu³

Affiliations

¹ Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Obstetric & Gynaecological and Paediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, China.
² Key Laboratory of Obstetric & Gynaecological and Paediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, China; Department of Ultrasonography, West China Second University Hospital, Sichuan University, Chengdu, China.
³ Department of Paediatrics, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Obstetric & Gynaecological and Paediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, China. Electronic address: mudz@scu.edu.cn.

PMID: 30553864
DOI: 10.1016/j.cmi.2018.12.006

Abstract

Background: Effective diagnostic methods for detecting latent tuberculosis infection (LTBI) are important for its eradication. A number of studies have evaluated the use of interferon-γ-induced protein 10 (IP-10), which is elevated after tuberculosis infection, as a biomarker for LTBI, but conclusive results regarding its effectiveness have not been reported.

Objectives: Our objective was to assess the diagnostic value of IP-10 for LTBI.

Data sources: We searched the PubMed, Embase, the Cochrane Library and Web of Science databases to find eligible studies.

Study eligibility criteria: We included cohort, case-control and cross-sectional studies that evaluated IP-10 in LTBI participants in comparison with tuberculin skin tests (TST) and interferon-γ release assays (IGRA).

Participants: Individuals with LTBI and uninfected participants.

Interventions: IP-10 (index test) compared with TST and IGRA (reference standard) for diagnosing LTBI.

Methods: PubMed, Embase, the Cochrane Library, and Web of Science databases were searched up to June 2018. A hierarchical summary receiver operating characteristic (HSROC) model was used to evaluate the pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and HSROC curve for the diagnostic efficiency of IP-10.

Results: Twelve studies including 1023 participants and 1122 samples were included. The overall pooled sensitivity was 0.85 (95% CI 0.80-0.88), specificity was 0.89 (95% CI 0.84-0.92), PLR was 7.55 (95% CI 5.20-10.97), NLR was 0.17 (95% CI 0.13-0.22) and DOR was 44.23 (95% CI 28.86-67.79), indicating a high accuracy for diagnosing LTBI. Based on a meta-regression analysis, high-burden countries, study design, IP-10 method, reference standard and the IP-10 cut-off could not explain the heterogeneity (p >0.05).

Conclusions: Our results suggested that IP-10 is a promising biomarker for the diagnosis of LTBI.

Keywords: Diagnosis; Interferon-γ-induced protein 10; Latent tuberculosis infection; Meta-analysis; Systematic review.

Publication types

Evaluation Study
Meta-Analysis
Systematic Review

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Biomarkers / blood*
Chemokine CXCL10 / blood*
Child
Child, Preschool
Cross-Sectional Studies
Female
Humans
Infant
Infant, Newborn
Interferon-gamma Release Tests
Latent Tuberculosis / diagnosis*
Male
Middle Aged
ROC Curve
Tuberculin Test
Young Adult

Substances

Biomarkers
CXCL10 protein, human
Chemokine CXCL10