Collapsing glomerulopathy: update

Med Clin (Barc). 2019 May 3;152(9):361-367. doi: 10.1016/j.medcli.2018.10.021. Epub 2018 Dec 13.
[Article in English, Spanish]


Collapsing glomerulopathy (CG) is a rare entity as a glomerular disease. Although it has been considered as a variant of focal segmental glomerulosclerosis, the fact is that the podocyte lesions show different features with respect to the typical focal segmental glomerulosclerosis, an aspect that has been attributed to a type of podocytopathy. In CG, the podocyte lesion is typically characterised by a dysregulated podocyte phenotype, reflected by the loss of expression of mature podocyte markers. CG can be a primary disease or it can be associated with several causal factors that develop a common histopathological entity. The clinical expressiveness of CG is often characterised by the presence of a nephrotic syndrome and a rapid deterioration of the renal function than other variants of the focal segmental glomerulosclerosis. The prognosis of these patients is a rapid progression towards end-stage renal disease with poor response to treatment.

Keywords: Collapsing glomerulopathy; Dedifferentiation podocytes; Desdiferenciación podocitaria; Glomerulopatía colapsante; Nephrotic range proteinuria; Podocitopatía; Podocytopathy; Proteinuria nefrótica.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Diagnosis, Differential
  • Glomerulonephritis* / diagnosis
  • Glomerulonephritis* / etiology
  • Glomerulonephritis* / physiopathology
  • Glomerulonephritis* / therapy
  • Glomerulosclerosis, Focal Segmental / diagnosis
  • Glomerulosclerosis, Focal Segmental / etiology
  • Glomerulosclerosis, Focal Segmental / physiopathology
  • Glomerulosclerosis, Focal Segmental / therapy
  • Humans
  • Kidney Failure, Chronic / diagnosis
  • Kidney Failure, Chronic / etiology
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / therapy
  • Nephrotic Syndrome / diagnosis
  • Nephrotic Syndrome / etiology
  • Nephrotic Syndrome / physiopathology
  • Nephrotic Syndrome / therapy
  • Prognosis
  • Risk Factors