Cognition in breast cancer survivors: A pilot study of interval and continuous exercise

Joseph M Northey; Kate L Pumpa; Clare Quinlan; Ashley Ikin; Kellie Toohey; Disa J Smee; Ben Rattray

doi:10.1016/j.jsams.2018.11.026

Cognition in breast cancer survivors: A pilot study of interval and continuous exercise

J Sci Med Sport. 2019 May;22(5):580-585. doi: 10.1016/j.jsams.2018.11.026. Epub 2018 Dec 6.

Authors

Joseph M Northey¹, Kate L Pumpa², Clare Quinlan², Ashley Ikin³, Kellie Toohey², Disa J Smee⁴, Ben Rattray²

Affiliations

¹ UC Research Institute for Sport and Exercise, University of Canberra, Australia; Discipline of Sport and Exercise Science, Faculty of Health, University of Canberra, Australia. Electronic address: joe.northey@canberra.edu.au.
² UC Research Institute for Sport and Exercise, University of Canberra, Australia; Discipline of Sport and Exercise Science, Faculty of Health, University of Canberra, Australia.
³ Discipline of Sport and Exercise Science, Faculty of Health, University of Canberra, Australia.
⁴ Discipline of Sport and Exercise Science, Faculty of Health, University of Canberra, Australia; Health Research Institute, Faculty of Health, University of Canberra, Australia.

PMID: 30554923
DOI: 10.1016/j.jsams.2018.11.026

Abstract

Objectives: The current study investigated the effects of two exercise interventions on cognitive function amongst breast cancer survivors.

Design: Pilot randomised-controlled trial.

Methods: Seventeen female cancer survivors (mean: 62.9±7.8years) were randomised into three groups: high-intensity interval training (HIIT, n=6); moderate-intensity continuous training (MOD, n=5); or wait-list control (CON, n=6). The HIIT and MOD groups exercised on a cycle ergometer 3days/week for 12-weeks. Primary outcomes were cognitive function assessments utilising CogState. Secondary outcomes were resting middle cerebral artery blood flow velocity, cerebrovascular reactivity and aerobic fitness (VO_2peak). Data were analysed with General Linear Mixed Models and Cohen's d effect sizes were calculated.

Results: All 17 participants who were randomised were available for follow-up analysis and adherence was similar for HIIT and MOD (78.7±13.2% vs 79.4±12.0%; p=0.93). Although there were no significant differences in the cognitive and cerebrovascular outcomes, HIIT produced moderate to large positive effects in comparison to MOD and CON for outcomes including episodic memory, working memory, executive function, cerebral blood flow and cerebrovascular reactivity. HIIT significantly increased VO_2peak by 19.3% (d=1.28) and MOD had a non-significant 5.6% (d=0.72) increase, compared to CON which had a 2.6% decrease.

Conclusions: This study provides preliminary evidence that HIIT may be an effective exercise intervention to improve cognitive performance, cerebrovascular function and aerobic fitness in breast cancer survivors. Considering the sample size is small, these results should be confirmed through larger clinical trials.

Keywords: Cardiorespiratory fitness; Cerebrovascular circulation; Cognitive function; High-intensity interval training.

Publication types

Randomized Controlled Trial

MeSH terms

Aged
Breast Neoplasms*
Cancer Survivors / psychology*
Cerebrovascular Circulation
Cognition*
Executive Function
Exercise
Female
High-Intensity Interval Training*
Humans
Memory, Episodic
Memory, Short-Term
Middle Aged
Pilot Projects