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Review
. 2019 Jan-Mar;9(1):96-110.
doi: 10.1016/j.jobcr.2018.11.003. Epub 2018 Nov 25.

Low-grade intraductal carcinoma of salivary glands: A systematic review of this rare entity

Francesco Giovacchini  1 , Caterina Bensi  2 , Stefano Belli  2 , Maria Elena Laurenti  3 , Martina Mandarano  3 , Daniele Paradiso  4 , Michele Giansanti  3 , Antonio Tullio  1   2   3   4   5
Affiliations
Free PMC article
Review

Low-grade intraductal carcinoma of salivary glands: A systematic review of this rare entity

Francesco Giovacchini et al. J Oral Biol Craniofac Res. 2019 Jan-Mar.
Free PMC article

Abstract

Background: Low-grade intraductal carcinomas are rare, malign tumors of salivary glands most commonly affecting parotid gland. It is a slow-growing tumor considered with a favourable prognosis after surgical excision.

Methods: To define the characteristics and management of low-grade intraductal carcinoma a systematic review was performed using the electronic databases Pubmed, Cochrane and Scopus. A new case report was also described.

Results: Including this case the review of literature identified only 54 cases reported thus far. Demographics, clinical presentation, diagnostic tools, treatment, follow-up and recurrence rate, histological and immunohistochemical patterns of this kind of tumor were summarized.

Conclusion: Low-grade intraductal carcinoma has already been well defined but is important to focus on the fact that in few cases component of high-grade infiltrations have been reported: this may modify surgical approach because a simple tumorectomy may not be enough.

Keywords: Low-grade cribriform cystadenocarcinoma; Low-grade intraductal carcinoma; Low-grade salivary duct carcinoma; Salivary glands tumor; Systematic review.

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Figures

Fig. 1
Fig. 1
a–d: low-grade intraductal carcinoma; e–f: intradermal infiltrating carcinoma, NOS; a. H&E; b p63; c Cytokeratin 14; d S100; e H&E; f Cytokeratin pool (CK5/6/8/18). Original Magnification ×20 (a, b, c, d), ×4 (e, f).
Fig. 2
Fig. 2
PRISMA flow chart of included studies.
See this image and copyright information in PMC

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