Transcriptomic data for analyzing global gene expression patterns in Methicillin-resistance Staphylococcus aureus in response to spermine and oxacillin stress

Shrikant Pawar; Xiangyu Yao; ChungDar Lu

doi:10.1016/j.dib.2018.11.090

Transcriptomic data for analyzing global gene expression patterns in Methicillin-resistance Staphylococcus aureus in response to spermine and oxacillin stress

Data Brief. 2018 Nov 23:21:2230-2236. doi: 10.1016/j.dib.2018.11.090. eCollection 2018 Dec.

Authors

Shrikant Pawar^{1

2}, Xiangyu Yao³, ChungDar Lu⁴

Affiliations

¹ Department of Biology, Georgia State University, 33 Gilmer Street SE, 30303 Atlanta, GA, USA.
² Department of Computer Science, Georgia State University, 33 Gilmer Street SE, 30303 Atlanta, GA, USA.
³ National Institutes of Health, 9000 Center Dr, 20892 Bethesda, MD, USA.
⁴ Department of Clinical Laboratory and Nutritional Sciences, Weed Hall 320, 01854-5125 Lowell, MA, USA.

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a rapidly emerging bacteria causing infection, which has developed resistance to most of the beta-lactam antibiotics because of newly acquired low-affinity penicillin binding protein (PBP2a), which can continue to build the cell wall when other PBPs are blocked by beta-lactams. Exogenous spermine exerts a dose dependent inhibition effect on the growth of E. coli, Salmonella enterica serovar and Staphylococcus aureus. We have selected an MRSA Mu50 derivative which harbors mutation on PBP2 gene (named as MuM) showing spermine resistance and which confers a complete abolishment of spermine-beta-lactam synergy. A transcriptomic profiling of MuM against Mu50 (wild type) without any treatment, MuM and Mu50 in response to high dose spermine and Mu50 in response to spermine-beta-lactam synergy is provided in this article. These comparisons will enhance our current understanding of mechanisms of spermine-beta-lactam synergy sensitization effects on MRSA.