Two myeloid leukemia cases with rare FLT3 fusions

Cold Spring Harb Mol Case Stud. 2018 Dec 17;4(6):a003079. doi: 10.1101/mcs.a003079. Print 2018 Dec.


Genetic rearrangements involving FLT3 are rare and only recently have been detected in myeloid/lymphoid neoplasms associated with eosinophilia (MLN-eos) and chronic myeloproliferative disorders. Here we report two cases with FLT3 fusions in patients demonstrating mixed features of myelodysplastic/myeloproliferative neoplasms. In the first case, FLT3 was fused with a new fusion partner MYO18A in a patient with marrow features most consistent with atypical chronic myeloid leukemia; the second case involving ETV6-FLT3 fusion was observed in a case with bone marrow features most consistent with chronic myelomonocytic leukemia. Notably, we observed that samples from both patients demonstrated FLT3 inhibitor (quizartinib and sorafenib) sensitivity in ex vivo drug screening assay.

Keywords: chronic myelomonocytic leukemia; transient myeloproliferative syndrome.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Benzothiazoles / pharmacology
  • Bone Marrow / pathology
  • Eosinophilia / genetics
  • Humans
  • Leukemia, Myeloid / genetics*
  • Leukemia, Myeloid / physiopathology
  • Leukemia, Myelomonocytic, Chronic / genetics
  • Lymphoma / genetics
  • Male
  • Middle Aged
  • Myelodysplastic-Myeloproliferative Diseases / genetics*
  • Myosins / genetics
  • Phenylurea Compounds / pharmacology
  • Proto-Oncogene Proteins c-ets / genetics
  • Recombination, Genetic / genetics
  • Repressor Proteins / genetics
  • Sorafenib / pharmacology
  • fms-Like Tyrosine Kinase 3 / genetics*
  • fms-Like Tyrosine Kinase 3 / physiology


  • Benzothiazoles
  • ETS translocation variant 6 protein
  • MYO18A protein, human
  • Phenylurea Compounds
  • Proto-Oncogene Proteins c-ets
  • Repressor Proteins
  • quizartinib
  • Sorafenib
  • FLT3 protein, human
  • fms-Like Tyrosine Kinase 3
  • Myosins