Circadian blueprint of metabolic pathways in the brain

Nat Rev Neurosci. 2019 Feb;20(2):71-82. doi: 10.1038/s41583-018-0096-y.


The circadian clock is an endogenous, time-tracking system that directs multiple metabolic and physiological functions required for homeostasis. The master or central clock located within the suprachiasmatic nucleus in the hypothalamus governs peripheral clocks present in all systemic tissues, contributing to their alignment and ultimately to temporal coordination of physiology. Accumulating evidence reveals the presence of additional clocks in the brain and suggests the possibility that circadian circuits may feed back to these from the periphery. Here, we highlight recent advances in the communications between clocks and discuss how they relate to circadian physiology and metabolism.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Biological Clocks
  • Brain / physiology*
  • Brain Chemistry / physiology*
  • Circadian Rhythm / physiology*
  • Eating
  • Humans
  • Metabolic Networks and Pathways / physiology*